Although the character must survive entirely on energy shield instead of life, immunity to chaos damage can be a significant advantage.
The chance and duration of both being stunned and receiving an elemental status ailments is based on your base life before CI takes effect. Maximum Life modifiers such as increased maximum Life, reduced maximum Life, etc. apply to the life before CI is applied. Since this base life value is then overwritten by CI, the only advantage life modifiers provide to a CI character is the reduction on stun and status ailment.
Chaos Inoculation no longer grants immunity degeneration effect of Blood RageBlood RageSpell, Duration
Mana Cost: (17-21)
Can Store 1 Use(s)
Cooldown Time: 1.00 secRequires Level 16Adds a buff that deals Physical Damage over time, while increasing Attack Speed and Life Leech. Killing an enemy while this buff is active refreshes the buff duration, and can grant a Frenzy Charge.Per 1% Quality:
0.25% increased Attack Speed(5-15)% increased Attack Speed
1.2% of Attack Physical Damage Leeched as Life
You take 4% of your Maximum Life per second as Physical Damage
You take 4% of your Maximum Energy Shield per second as Physical Damage
25% chance to gain a Frenzy Charge on Kill
Base duration is (7-10.8) secondsPlace into an item socket of the right colour to gain this skill. Right click to remove from a socket. while retaining other benefits of the skill as of 2.0.0 with the Blood Rage degeneration damage type changing to physical.
Low life conditions will never trigger while CI is enabled. Effects such as Pain Attunement and On Low Life mods on gear will not activate. For these effects, you must have 35% or less of your current maximum life. Chaos Inoculation sets your maximum life to 1.
Full life conditions will always trigger because you are always at 100% of 1 life.
Interaction with life reduction
Life reductions apply before CI which resets life to 1. For example from Ephemeral EdgeEphemeral Edge
Dusk BladeOne Handed Sword
Physical Damage: 51.3–145.8
Critical Strike Chance: 5.00%
Attacks per Second: 1.30
Weapon Range: 9Requires Level 32, 57 Str, 57 Dex40% increased Global Accuracy Rating150% increased Physical Damage
+10 to Intelligence
50% increased Global Critical Strike Chance
(0.6-1)% of Physical Attack Damage Leeched as Mana
10% reduced maximum Life
(40-50)% increased maximum Energy ShieldIn the rift between future and past,
life passes quickly..
When linked with Blood Magic SupportBlood Magic SupportSupport
Mana Multiplier: (245%-196%)Requires Level 31Supports any skill.Per 1% Quality:
Supported Skills have 0.5% reduced Mana CostSupported Skills Spend Life instead of ManaThis is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Active Skill Gem you wish to augment. Right click to remove from a socket., affected skills cannot be cast, even if it is an aura which would drain a relative amount of mana/health.
Chaos resistance reduction/penetration
It is generally best to wait until you have high energy shield before taking CI because it's much easier to survive on life at lower levels. Don't be afraid to take life passive skills for survivability while leveling up, since you can remove them later.
Characters with CI are usually more susceptible to stun and status ailments because of their low base life. Rather than taking otherwise useless life nodes as described above, Stun can be mitigated by increasing the Stun Recovery stat with items and passives or unique items such as Eye of ChayulaEye of Chayula
Onyx AmuletRequires Level 20+(10-16) to all Attributes20% reduced maximum Life
30% increased Rarity of Items found
Cannot be StunnedNever blinking, always watching.
This item can be transformed with a Blessing of Chayula, SkyforthSkyforth
Sorcerer BootsQuality: +20%
Energy Shield: 58Requires Level 67, 123 Int+(60-120) to maximum Mana
30% increased Movement Speed
25% chance to gain a Power Charge on Critical Strike
6% reduced Mana Reserved
You have no Life Regeneration
Stun Threshold is based on 500% of your Mana instead of LifeThe quick die young, the brilliant go mad,
and the powerful stand alone in a wasteland of their own creation., and ValyriumValyrium
Moonstone RingRequires Level 38+(15-25) to maximum Energy Shield+(10-20) to maximum Energy Shield
+(20-30)% to Fire Resistance
-40% to Cold Resistance
Stun Threshold is based on Energy Shield instead of LifeThey will rise and fall in fire and blood.. Status ailments can be reduced with high elemental resistances or unique items such as AuxiumAuxium
Crystal BeltRequires Level 79+(60-80) to maximum Energy Shield+(45-55) to maximum Mana
+(60-70) to maximum Energy Shield
0.2% of Attack Damage Leeched as Mana per Power Charge
(20-25)% increased Elemental Damage with Attack Skills per Power Charge
Chill Effect and Freeze Duration on you are based on 100% of Energy ShieldAs long as the soul is unfettered, so is the body. or Dream FragmentsDream Fragments
Sapphire RingRequires Level 24+(20-30)% to Cold Resistance20% increased maximum Mana
50% increased Mana Regeneration Rate
Cannot be Chilled
Cannot be Frozen
+(30-40)% to Cold ResistanceDoryani stumbled into a realm of madness
And awoke its Master..
Chaos Inoculation works well with some other keystone passives, such as:
- Ghost Reaver converts life gained from life leech into energy shield. Vaal Pact only disables any regeneration granted from passives that's converted by Zealot's Oath as of 3.0.0
- Zealot's Oath applies life regeneration to energy shield. Regen effects that are based on maximum life become based on maximum ES. Note that "regeneration" does not include life flasks, as they are just "Recovery".
- Dan_GGG (February 11, 2016). "Chaos Penetration vs CI?". Path of Exile Forums. Retrieved February 11, 2016.