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Chaos Inoculation

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Chaos Inoculation
KeystoneChaosInoculation passive skill icon.png
Maximum Life becomes 1, Immune to Chaos Damage [1]
Give up everything in pursuit of greatness - even life itself.

Chaos Inoculation (often referred to as CI) is a keystone passive skill that grants immunity to chaos damage, but sets maximum life to 1.

Although the character must survive entirely on energy shield instead of life, immunity to chaos damage can be a significant advantage.


The chance and duration of both being stunned and receiving an elemental status ailments is based on your base life before CI takes effect. Maximum Life modifiers such as increased maximum Life, reduced maximum Life, etc. apply to the life before CI is applied. Since this base life value is then overwritten by CI, the only advantage life modifiers provide to a CI character is the reduction on stun and status ailment.

Chaos Inoculation no longer grants immunity degeneration effect of Blood RageBlood RageSpell, Duration, Physical
Mana Cost: (7-16)
Can Store 1 Use(s)
Cooldown Time: 1.00 sec
Requires Level 16Adds a buff that deals Physical Damage over time, while increasing Attack Speed and Life Leech. Killing an enemy while this buff is active refreshes the buff duration, and can grant a Frenzy Charge.Per 1% Quality:
0.25% increased Attack Speed
(5-15)% increased Attack Speed
1.2% of Attack Physical Damage Leeched as Life
You take 4% of your Maximum Life per second as Physical Damage
You take 4% of your Maximum Energy Shield per second as Physical Damage
25% chance to gain a Frenzy Charge on Kill
Base duration is (7-10.8) seconds
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
Blood Rage skill icon.png
while retaining other benefits of the skill as of 2.0.0 with the Blood Rage degeneration damage type changing to physical.

Low life conditions will never trigger while CI is enabled. Effects such as Pain Attunement and On Low Life mods on gear will not activate. For these effects, you must have 35% or less of your current maximum life. Chaos Inoculation sets your maximum life to 1.

Full life conditions will always trigger because you are always at 100% of 1 life.

Interaction with life reduction

Life reductions apply before CI which resets life to 1. For example from Ephemeral EdgeEphemeral Edge
Dusk Blade
One Handed Sword
Quality: +20%
Physical Damage: 51.3145.8
Critical Strike Chance: 5.00%
Attacks per Second: 1.30
Weapon Range: 11
Requires Level 32, 57 Str, 57 Dex40% increased Global Accuracy Rating+10 to Intelligence
150% increased Physical Damage
50% increased Global Critical Strike Chance
(40-50)% increased maximum Energy Shield
10% reduced maximum Life
(0.6-1)% of Physical Attack Damage Leeched as Mana
In the rift between future and past,
life passes quickly.

Blood magic

When linked with Blood Magic SupportBlood Magic SupportSupport
Icon: B
Mana Multiplier: (245%-196%)
Requires Level 31Supports any skill.Per 1% Quality:
Supported Skills have 0.5% reduced Mana Cost
Supported Skills Spend Life instead of ManaThis is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Active Skill Gem you wish to augment. Right click to remove from a socket.
, affected skills cannot be cast, even if it is an aura which would drain a relative amount of mana/health.

Chaos resistance reduction/penetration

Since CI grants a flat-out immunity to chaos damage, effects that reduce or penetrate chaos resistance (i.e. Occultist's Void Beacon) have no effect against CI.[1]

CI builds

It is generally best to wait until you have high energy shield before taking CI because it's much easier to survive on life at lower levels. Don't be afraid to take life passive skills for survivability while leveling up, since you can remove them later.

Characters with CI are usually more susceptible to stun and status ailments because of their low base life. Rather than taking otherwise useless life nodes as described above, Stun can be mitigated by increasing the Stun Recovery stat with items and passives or unique items such as Eye of ChayulaEye of Chayula
Onyx Amulet
Requires Level 20+(10-16) to all Attributes20% reduced maximum Life
30% increased Rarity of Items found
Cannot be Stunned
Never blinking, always watching.

This item can be transformed with a Blessing of Chayula
, SkyforthSkyforth
Sorcerer Boots
Quality: +20%
Energy Shield: 58
Requires Level 67, 123 Int+(60-120) to maximum Mana
30% increased Movement Speed
25% chance to gain a Power Charge on Critical Strike
6% reduced Mana Reserved
You have no Life Regeneration
Stun Threshold is based on 500% of your Mana instead of Life
The quick die young, the brilliant go mad,
and the powerful stand alone in a wasteland of their own creation.
, and ValyriumValyrium
Moonstone Ring
Requires Level 38+(15-25) to maximum Energy Shield+(30-40) to maximum Energy Shield
+(30-40)% to Fire Resistance
-40% to Cold Resistance
Stun Threshold is based on Energy Shield instead of Life
They will rise and fall in fire and blood.
. Status ailments can be reduced with high elemental resistances, Elementalist's Elemancer perk with at least 3 golems, or unique items such as AuxiumAuxium
Crystal Belt
Requires Level 79+(60-80) to maximum Energy Shield+(60-70) to maximum Energy Shield
+(45-55) to maximum Mana
Chill Effect and Freeze Duration on you are based on 100% of Energy Shield
(20-25)% increased Elemental Damage with Attack Skills per Power Charge
0.2% of Attack Damage Leeched as Mana per Power Charge
As long as the soul is unfettered, so is the body.
or Dream FragmentsDream Fragments
Sapphire Ring
Requires Level 24+(20-30)% to Cold Resistance20% increased maximum Mana
50% increased Mana Regeneration Rate
+(30-40)% to Cold Resistance
Cannot be Chilled
Cannot be Frozen
Doryani stumbled into a realm of madness
And awoke its Master.

Chaos Inoculation works well with some other keystone passives, such as:

  • Ghost Reaver converts life gained from life leech into energy shield. Vaal Pact only disables any regeneration granted from passives that's converted by Zealot's Oath as of 3.0.0
  • Zealot's Oath applies life regeneration to energy shield. Regen effects that are based on maximum life become based on maximum ES. Note that "regeneration" does not include life flasks, as they are just "Recovery".


Chaos Inoculation is located on the northeast edge of the skill tree.

Class Distance from start
Witch 9
Shadow 11
Scion 14
Templar 16
Ranger 19
Marauder 23
Duelist 25

Related unique items

ItemBase ItemLvl.Stats
Midnight BargainMidnight Bargain
Engraved Wand
Quality: +20%
Physical Damage: 20.438.4
Critical Strike Chance: 7.00%
Attacks per Second: 1.50
Weapon Range: 120
Requires Level 40, 131 Int(22-26)% increased Spell Damage+(10-20) to Intelligence
Minions have (20-30)% increased Movement Speed
Minions deal (50-70)% increased Damage
+1 to maximum number of Raised Zombies
+1 to maximum number of Skeletons
+1 to maximum number of Spectres
Reserves 30% of Life
Cannot be used with Chaos Inoculation
A chilling hush, a scraping sound
Of things no more entombed in ground.
A shambling horde is on its way
To crush the very light of day.
Engraved Wand40(22-26)% increased Spell Damage+(10-20) to Intelligence
Minions have (20-30)% increased Movement Speed
Minions deal (50-70)% increased Damage
+1 to maximum number of Raised Zombies
+1 to maximum number of Skeletons
+1 to maximum number of Spectres
Reserves 30% of Life
Cannot be used with Chaos Inoculation

Version history

Version Changes
  • Vaal Pact now only applies to leeched life.
  • The passive skills behind Chaos Inoculation have been removed.
  • Fixed an issue where players' life totals could get out of sync when they died from degeneration damage with Chaos Inoculation allocated.
  • Chaos Inoculation now grants no additional energy shield bonus. Its complete immunity to chaos damage, synergy with Blood Rage and other skill combos are deemed sufficient upside to counteract the life penalty.
  • The Chaos Inoculation keystone passive skill now grants +50% Energy Shield rather than +80%.
  • Fixed the interaction between Chaos Inoculation and Blood Magic so that there's no crazy bugged death state any more. If you try to reserve life or mana when you have both of these keystones, you will now die properly.
  • Changed the Chaos Inoculation keystone so that your "real" life value is still used for checks related to stun and elemental status ailments. This will mean that you don't receive giant stuns/chills due to being reduced to 1 life.
  • Chaos Inoculation now grants a multiplicative increase to Energy Shield.
  • Chaos Inoculation now grants +80% energy shield rather than +20%
  • Added 12 Keystone Passives.
  • Chaos Innoculation: 20% increased maximum energy shield. Provides immunity to chaos damage. Maximum life becomes 1.


  1. Dan_GGG (February 11, 2016). "Chaos Penetration vs CI?". Path of Exile Forums. Retrieved February 11, 2016.