Alira's Amulet is a quest item acquired after defeating Alira in the Western Forest. It is only obtainable during one of the bandit faction quests in Act 2 that requires the character to oppose Alira: "Deal with the Bandits", "The Bandit Lord Oak", or "The Bandit Lord Kraityn".
If combined with Oak's AmuletOak's AmuletA relic of a sundered relationship, it awaits reconciliation with its kin. and Kraityn's AmuletKraityn's AmuletWhile this artefact resonates with power, it is simply a piece in a larger puzzle., The ApexThe ApexThough its power has been shared, there is still more the Apex might unlock. is formed.